Acute myeloid leukemia with inv(16)(p13q22): involvement of cervical lymph nodes and tonsils is common and may be a negative prognostic sign.

摘要: Acute myeloid leukemia (AML) with inv(16)(p13q22) or the variant t(16;16)(p13;q22), is strongly associated FAB subtype M4Eo. A high incidence of CNS involvement was reported in 1980s, but otherwise little known about pattern extamedullary (EML) manifestations this AML type. We have compiled clinical and cytogenetic data on 27 consecutive cases inv(16)/t(16;16) from southern Sweden. In general, these AMLs displayed features that previously been described as characteristic for disease entity: low median age, hyperleukocytosis, M4Eo morphology, a favorable prognosis. However, only seen relapse one patient diagnosed 1980, whereas most common EML manifestation our series lymphadenopathy (5/27, 19%), often cervical without gross tonsillar enlargement. review published, clinically informative corroborates lymphadenopathy, preference region, at diagnosis inv(16)-positive (58/175, 33%). leukemia, other hand, has 17% cases, mostly setting, diminishing frequency over time, possibly due to protective effects high-dose cytarabine. Other sites include scalp, ovaries, intestine. Cervicotonsillar shorter duration first remission, (P < 0.05), may hence prove be an important parameter when deciding treatment strategies inv(16)/t(16;16).