Hematologic and cytologic characterization of 8/21 translocation acute granulocytic leukemia.

摘要: Cytogenetic studies were performed in 546 patients with acute leukemia between 1968 and 1975. Two hundred thirty-four aneuploid (42.9%), 312 diploid (57.1%). Among these, 32 found to exhibit similar chromosomal alterations that appeared involve specifically chromosomes 8 21. Banding at least 15 of these confirmed the presence a translocation two chromosomes. The cytogenetic findings correlated hematologic clinical data. It was each individuals had typical picture granulocytic Auer rod-positive peroxidase-positive cells. Ultrastructurally, this group also consistently demonstrated nuclear bleb has been positively associated aneuploidy leukemia. Clinically, they seemed respond better therapy than other adult is proposed 8/21 represents definite subgroup within general category leukemia, an incidence approximately 7.3%.