Mixed-lineage leukemia revisited: acute lymphocytic leukemia with myeloperoxidase-positive blasts by electron microscopy.
作者： HM Kantarjian , C Hirsch-Ginsberg , G Yee , Y Huh , EJ Freireich
DOI: 10.1182/BLOOD.V76.4.808.808
关键词: Acute lymphocytic leukemia 、 Antibody 、 Vincristine 、 Induction chemotherapy 、 Myeloperoxidase 、 Leukemia 、 Pathology 、 Immunophenotyping 、 Biology 、 T cell
摘要: Seven adult patients with untreated acute lymphocytic leukemia (ALL) who manifested 5% to 40% myeloperoxidase (MPO)-positive blasts by electron microscopy (EM) are reported. Six had an L2 morphology, and one L1 morphology the French-American-British (FAB) classification. The immunophenotype was T cell in four patients. Molecular analysis showed rearrangement of immunoglobulin JH patients, three them also having T-cell receptor beta or gamma. Induction chemotherapy vincristine- doxorubicin-dexamethasone (VAD) produced a complete remission five six (83%). Our findings suggest existence previously undescribed subtype mixed-lineage leukemia, which often appears as ALL but exhibits MPO-positive EM.
ashpublications.org
sci-hub.st 参考文章(22)
JM Trujillo, A Cork, MJ Ahearn, EL Youness, KB McCredie, Hematologic and cytologic characterization of 8/21 translocation acute granulocytic leukemia. Blood. ,vol. 53, pp. 695- 706 ,(1979) , 10.1182/BLOOD.V53.4.695.695
Joseph Mirro, Sanford A. Stass, Lineage heterogeneity in acute leukaemia: acute mixed-lineage leukaemia and lineage switch. Clinics in haematology. ,vol. 15, pp. 811- 827 ,(1986) , 10.1016/S0308-2261(18)30012-2
PB Neame, P Soamboonsrup, G Browman, RD Barr, N Saeed, B Chan, M Pai, A Benger, WE Wilson, IR Walker, Simultaneous or sequential expression of lymphoid and myeloid phenotypes in acute leukemia. Blood. ,vol. 65, pp. 142- 148 ,(1985) , 10.1182/BLOOD.V65.1.142.142
S Ferrari, MT Mariano, E Tagliafico, M Sarti, G Ceccherelli, L Selleri, F Merli, F Narni, A Donelli, G Torelli, Myeloperoxidase Gene Expression in Blast Cells With a Lymphoid Phenotype in Cases of Acute Lymphoblastic Leukemia Blood. ,vol. 72, pp. 873- 876 ,(1988) , 10.1182/BLOOD.V72.3.873.873
E. M. Simpson, M. G. Mott, Hybrid leukaemia of T cell and myeloid lineages: cytogenetic distinction from second (induced) malignancy British Journal of Haematology. ,vol. 65, pp. 401- 403 ,(1987) , 10.1111/J.1365-2141.1987.TB04140.X
M. S. Hershfield, J. Kurtzberg, E. Harden, J. O. Moore, J. Whang-Peng, B. F. Haynes, Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 253- 257 ,(1984) , 10.1073/PNAS.81.1.253
Ching-Hon Pui, Frederick G. Behm, Susana C. Raimondi, Richard K. Dodge, Stephen L. George, Gaston K. Rivera, Joseph Mirro, David K. Kalwinsky, Gary V. Dahl, Sharon B. Murphy, William M. Crist, Dorothy L. Williams, Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. The New England Journal of Medicine. ,vol. 321, pp. 136- 142 ,(1989) , 10.1056/NEJM198907203210302
Yasuhide Hayashi, Yukio Kobayashi, Hisamaru Hirai, Ryoji Hanada, Keiko Yamamoto, Takashi Abe, Kanji Sugita, Sinpei Nakazawa, Noriyuki Suetake, Hiroo Hoshino, Takayoshi Kuroume, Fumio Bessho, Hiroshi Hayakawa, Fumimaro Takaku, Immunoglobulin heavy chain gene rearrangements and mixed lineage characteristics in acute leukemias with the 11;19 translocation Cancer. ,vol. 61, pp. 712- 720 ,(1988) , 10.1002/1097-0142(19880215)61:4<712::AID-CNCR2820610414>3.0.CO;2-6
Sanford Stass, Joseph Mirro, Unexpected heterogeneity in acute leukemia: Mixed lineages and lineage switch Human Pathology. ,vol. 16, pp. 864- 866 ,(1985) , 10.1016/S0046-8177(85)80125-8
Anand Raghavachar, Claus R. Bartram, Gerhard Gaedicke, Thomas Binder, Gerhard Heil, Felix Carbonell, Bernhard Kubanek, Enno Kleihauer, Conversion of acute undifferentiated leukemia phenotypes: analysis of clonal development. Leukemia Research. ,vol. 10, pp. 1293- 1299 ,(1986) , 10.1016/0145-2126(86)90336-X