Central Nervous System Involvement in Acute Myeloid Leukemia Patients Undergoing Hematopoietic Cell Transplantation
作者： Merav Bar , Weigang Tong , Megan Othus , Keith R. Loeb , Elihu H. Estey
DOI: 10.1016/J.BBMT.2014.11.683
关键词:
摘要: Knowledge regarding the rate of central nervous system (CNS) involvement and risk factors for its development in acute myeloid leukemia (AML) patients undergoing allogeneic hematopoietic cell transplantation (HCT) are limited. In this study we retrospectively evaluated CNS 327 who underwent myeloablative HCT at our institute which all have cerebrospinal fluid examined by morphology or flow cytometry before HCT. Twenty-two (7%) had AML pre-HCT evaluation. Covariates associated with such were higher WBC diagnosis, prior other extramedullary disease, evidence systemic disease History status evaluation allowed stratification into 3 groups: 35% (20 patients), 16% (51 3% (256 patients) rates involvement. Treatment was uniformly successful regardless whether cranial irradiation therapy used. Perhaps as a result, presence no independent influence on post-HCT outcome, primarily influenced time
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