Leptomeningeal metastasis from systemic cancer: Review and update on management.
作者： Nancy Wang , Mia S. Bertalan , Priscilla K. Brastianos
DOI: 10.1002/CNCR.30911
关键词: Cancer 、 Radiology 、 Brain metastasis 、 Medicine 、 Magnetic resonance imaging of the brain 、 Multimodal therapy 、 Disease 、 Chemotherapy 、 Treatment resistance 、 Leptomeningeal metastasis
摘要: Leptomeningeal metastasis is an uncommon and typically late complication of cancer with a poor prognosis and limited treatment options. Diagnosis is often challenging, with nonspecific presenting symptoms ranging from headache and confusion to focal neurologic deficits, such as cranial nerve palsies. Standard diagnostic evaluation involves a neurologic examination, magnetic resonance imaging of the brain and spine with gadolinium, and cytologic evaluation of the cerebral spinal fluid. Therapy entails a multimodal approach …
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