Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses.

摘要: This study addresses the relative importance of CD134 (OX40) and CD137 (4-1BB) in costimulation CD4+ CD8+ T cells under comparable conditions antigenic stimulation. We demonstrate that is capable directly costimulating cells. However, by less potent than triggered CD137. The higher costimulatory activity CD137, when compared with CD134, correlates well its faster expression kinetics levels on Furthermore, induction highly sensitive to low TCR stimulation, which contrast CD134. Conversely, more effective This, however, could not be attributed differential expression. also transient nature activated resultof proteolytic shedding. Consistent greater ability costimulate cells, stimulation vivo considerably augmenting anti-tumor immune responses. Therefore, agents stimulate signaling via are likely useful clinical where CTL responses required.