Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol.
作者： Beverley S. Alexander , Martyn D. Wood
DOI: 10.1111/J.2042-7158.1987.TB03452.X
关键词: In vitro 、 Enantiomer 、 Serotonin 、 Blockade 、 Ketanserin 、 Stereoselectivity 、 Stereochemistry 、 Propranolol 、 Mianserin 、 Pharmacology 、 Chemistry
摘要: The interaction of the enantiomers mianserin and propranolol with binding [3H]5-hydroxytryptamine ([3H]5-HT) to 5-HT1A, 5-HT1B 5-HT1C sites, [3H]ketanserin 5-HT2 site, has been evaluated in rat brain membranes. A stereoselective at sites was demonstrated for both compounds, (-)-mianserin being a more potent displacer than (-)–mianserin (-)-propranolol (+)-propranolol. Only interacted manner (+)-mianserin isomer. association may prove useful characterization these sites.
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