Tactile teaching: Exploring protein structure/function using physical models*.
作者： Tim Herman , Jennifer Morris , Shannon Colton , Ann Batiza , Michael Patrick
DOI: 10.1002/BMB.2006.494034042649
关键词: Physical model 、 Mathematics education 、 Protein structure function 、 Protein structure prediction 、 Protein structure and function 、 School level 、 Atomic coordinates 、 Professional development 、 Construct (philosophy)
摘要: The technology now exists to construct physical models of proteins based on atomic coordinates solved structures. We review here our recent experiences in using teach concepts protein structure and function at both the high school undergraduate levels. At level, are used a professional development program targeted biology chemistry teachers. This has recently been expanded include two student enrichment programs which students participate modeling activities. we currently exploring usefulness communicating that have traditionally difficult teach. discuss experience with such examples: close-packed nature an enzyme active site pH-induced conformational change influenza hemagglutinin during virus infection.
sci-hub.se 参考文章(19)
Thomas R. Mueller, Learning to Think Spatially Photogrammetric Engineering and Remote Sensing. ,vol. 72, pp. 1005- 1006 ,(2006)
Nenad Ban, Poul Nissen, Jeffrey Hansen, Malcolm Capel, Peter B. Moore, Thomas A. Steitz, Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit. Nature. ,vol. 400, pp. 841- 847 ,(1999) , 10.1038/23641
Per A. Bullough, Frederick M. Hughson, John J. Skehel, Don C. Wiley, Structure of influenza haemagglutinin at the pH of membrane fusion Nature. ,vol. 371, pp. 37- 43 ,(1994) , 10.1038/371037A0
Hsin-Kai Wu, Priti Shah, Exploring visuospatial thinking in chemistry learning Science Education. ,vol. 88, pp. 465- 492 ,(2004) , 10.1002/SCE.10126
Kenneth A. Bradley, Jeremy Mogridge, Michael Mourez, R. John Collier, John A. T. Young, Identification of the cellular receptor for anthrax toxin. Nature. ,vol. 414, pp. 225- 229 ,(2001) , 10.1038/N35101999
Andrew D. Pannifer, Thiang Yian Wong, Robert Schwarzenbacher, Martin Renatus, Carlo Petosa, Jadwiga Bienkowska, D. Borden Lacy, R. John Collier, Sukjoon Park, Stephen H. Leppla, Philip Hanna, Robert C. Liddington, Crystal structure of the anthrax lethal factor Nature. ,vol. 414, pp. 229- 233 ,(2001) , 10.1038/N35101998
Mylène Weill, Georges Lutfalla, Knud Mogensen, Fabrice Chandre, Arnaud Berthomieu, Claire Berticat, Nicole Pasteur, Alexandre Philips, Philippe Fort, Michel Raymond, Insecticide resistance in mosquito vectors Nature. ,vol. 423, pp. 136- 137 ,(2003) , 10.1038/423136B
Gordon A. Bain, John Yi, Mithra Beikmohamadi, Timothy M. Herman, Michael A. Patrick, Using Physical Models of Biomolecular Structures To Teach Concepts of Biochemical Structure and Structure Depiction in the Introductory Chemistry Laboratory Journal of Chemical Education. ,vol. 83, pp. 1322- 1324 ,(2006) , 10.1021/ED083P1322
Carlo Petosa, R. John Collier, Kurt R. Klimpel, Stephen H. Leppla, Robert C. Liddington, Crystal structure of the anthrax toxin protective antigen. Nature. ,vol. 385, pp. 833- 838 ,(1997) , 10.1038/385833A0
Roger Sayle, James Milner-White, RASMOL: biomolecular graphics for all Trends in Biochemical Sciences. ,vol. 20, pp. 374- 376 ,(1995) , 10.1016/S0968-0004(00)89080-5