Identification of the cellular receptor for anthrax toxin.
作者： Kenneth A. Bradley , Jeremy Mogridge , Michael Mourez , R. John Collier , John A. T. Young
DOI: 10.1038/N35101999
关键词: Receptor 、 Anthrax vaccines 、 Bacillus anthracis 、 Anthrax toxin 、 Protein kinase A 、 Pore-forming toxin 、 Anthrax toxin receptor 2 、 Anthrax Toxin Receptor 1 、 Biology 、 Microbiology
摘要: The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps bacterium evade immune system and can kill host during a systemic infection. Two components enzymatically modify substrates within cytosol mammalian cells: oedema factor (OF) is an adenylate cyclase that impairs defences through variety mechanisms including inhibiting phagocytosis; lethal (LF) zinc-dependent protease cleaves mitogen-activated protein kinase causes lysis macrophages. Protective antigen (PA), third component, binds to cellular receptor mediates delivery enzymatic cytosol. Here we describe cloning human PA using genetic complementation approach. receptor, termed ATR (anthrax receptor), type I membrane with extracellular von Willebrand A domain directly PA. In addition, soluble version this protect cells from action toxin.
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