L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

作者： Mark S. Shearman , Dirk Beher , Earl E. Clarke , Huw D. Lewis , Tim Harrison

DOI: 10.1021/BI0005456

关键词: P3 peptide 、 Protein precursor 、 Peptide sequence 、 Biochemistry 、 Chemistry 、 Presenilin 、 Gene mutation 、 Molecular mimicry 、 Structure–activity relationship 、 Amyloid precursor protein secretase