Dnmt1 structure and function.

摘要: Dnmt1, the principal DNA methyltransferase in mammalian cells, is a large and highly dynamic enzyme with multiple regulatory features that can control methylation cells. This chapter highlights how insights into Dnmt1 structure function advance our understanding of The allosteric site(s) on regulate processes de novo maintenance Remaining open questions include which molecules, by what mechanism, bind at cells? Different phosphorylation sites change its activity or ability to target sites. Thirty-one different molecules are currently known have physical and/or functional interaction enzymatic mechanism offer unique those interactions. interacting involved chromatin organization, repair, cell cycle regulation, apoptosis also RNA polymerase II, some RNA-binding proteins, specific Dnmt1-inhibitory molecules. Combined from studies novel ideas for development drug candidates, be used selection promising candidates more than 15 compounds been identified as possible inhibitors