DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

作者: Michael R. Rountree , Kurtis E. Bachman , Stephen B. Baylin

DOI: 10.1038/77023

关键词:

摘要: … DNMT1 may complex with a HDAC. We next conducted co-immunoprecipitations to determine whether DNMT1 was associated with one of the major HDACs… DNMT1-DMAP1 interaction …

参考文章(48)
Elizabeth E. Cameron, Kurtis E. Bachman, Sanna Myöhänen, James G. Herman, Stephen B. Baylin, Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer Nature Genetics. ,vol. 21, pp. 103- 107 ,(1999) , 10.1038/5047
Peter L. Jones, Gert Jan C. Veenstra, Paul A. Wade, Danielle Vermaak, Stefan U. Kass, Nicoletta Landsberger, John Strouboulis, Alan P. Wolffe, Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genetics. ,vol. 19, pp. 187- 191 ,(1998) , 10.1038/561
En Li, The mojo of methylation Nature Genetics. ,vol. 23, pp. 5- 6 ,(1999) , 10.1038/12595
François Fuks, Wendy A. Burgers, Alexander Brehm, Luke Hughes-Davies, Tony Kouzarides, DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nature Genetics. ,vol. 24, pp. 88- 91 ,(2000) , 10.1038/71750
A T Annunziato, R L Seale, Histone deacetylation is required for the maturation of newly replicated chromatin. Journal of Biological Chemistry. ,vol. 258, pp. 12675- 12684 ,(1983) , 10.1016/S0021-9258(17)44229-3
Wen Hwa Lee, Yumay Chen, Qing Zhong, Diane Jones, Perturbation of TSG101 Protein Affects Cell Cycle Progression Cancer Research. ,vol. 58, pp. 2699- 2702 ,(1998)
Huck-Hui Ng, Yi Zhang, Brian Hendrich, Colin A. Johnson, Bryan M. Turner, Hediye Erdjument-Bromage, Paul Tempst, Danny Reinberg, Adrian Bird, MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nature Genetics. ,vol. 23, pp. 58- 61 ,(1999) , 10.1038/12659
Xinsheng Nan, Huck-Hui Ng, Colin A. Johnson, Carol D. Laherty, Bryan M. Turner, Robert N. Eisenman, Adrian Bird, Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex Nature. ,vol. 393, pp. 386- 389 ,(1998) , 10.1038/30764