A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children.

摘要: Objective To perform a randomized controlled trial comparing moxifloxacin hydrochloride with polymyxin B-trimethoprim for the treatment of acute conjunctivitis. Study design Patients ages 1-18 years old conjunctivitis had cultures performed and were to receive either or ophthalmic solution 7 days. Response was determined by phone query on day 4-6 examination post-treatment conjunctival culture 7-10. Results One hundred twenty-four patients enrolled. Eighty (65%) recognized pathogens (55 Haemophilus influenzae , 22 Streptococcus pneumoniae 4 Moraxella catarrhalis ) isolated from their conjunctiva. fourteen (56/62 58/62 B-trimethoprim) completed evaluation, 43/56 (77%) group 42/58 (72%) clinically cured according parents (noninferiority test P  = .04). Eighty-nine (39/56 50/58 7-10 evaluation. Clinical cure observed in 37/39 (95%) 49/51 (96%) treated groups  ≤ .01). rates positive negative not different. There no statistically significant difference bacteriologic between 2 groups. Conclusions Polymyxin continues be an effective clinical response rate that does differ moxifloxacin. Use would result cost savings compared fluoroquinolones.