Systematic Review on Therapeutic Strategies to Minimize Corneal Stromal Scarring After Injury.

作者: Sum S. Kwok , Kendrick C. Shih , Yashan Bu , Amy C.-Y. Lo , Tommy C.-Y. Chan

DOI: 10.1097/ICL.0000000000000584

关键词: PharmacotherapyMEDLINEOphthalmic solutionsCorneaEntrezStromal cellOphthalmologyMedicine

摘要: Objectives:To evaluate recent studies on available and experimental therapies in preventing or minimizing corneal stromal scarring after injury.Methods:We performed an Entrez PubMed literature search using keywords “cornea,” “scarring,” “haze,” “opacity,” “ulcer,” “treatments,” “therapies,” “treatme

参考文章(43)
J Krumeich, A Knülle, B Krumeich, [Deep anterior lamellar (DALK) vs. penetrating keratoplasty (PKP): a clinical and statistical analysis]. Klinische Monatsblatter Fur Augenheilkunde. ,vol. 225, pp. 637- 648 ,(2008) , 10.1055/S-2008-1027485
Atsuhito Nakao, Mozhgan Afrakhte, Anita Morn, Takuya Nakayama, Jan L. Christian, Rainer Heuchel, Susumu Itoh, Masahiro Kawabata, Nils-Erik Heldin, Carl-Henrik Heldin, Peter ten Dijke, Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling Nature. ,vol. 389, pp. 631- 635 ,(1997) , 10.1038/39369
Stephen I. Rennard, Fu-Qiang Wen, Tadashi Kohyama, C. Magnus Sköld, Yun Kiu Zhu, Xiangde Liu, Debra J. Romberger, Julie Stoner, Glucocorticoids modulate TGF-β production Inflammation. ,vol. 26, pp. 279- 290 ,(2002) , 10.1023/A:1021412601538
Dylan G. Buss, Ajay Sharma, Elizabeth A. Giuliano, Rajiv R. Mohan, Efficacy and safety of mitomycin C as an agent to treat corneal scarring in horses using an in vitro model. Veterinary Ophthalmology. ,vol. 13, pp. 211- 218 ,(2010) , 10.1111/J.1463-5224.2010.00782.X
Haijing Wang, Yaoguang Zhang, Zhijian Li, Tiebin Wang, Ping Liu, Prevalence and causes of corneal blindness Clinical and Experimental Ophthalmology. ,vol. 42, pp. 249- 253 ,(2014) , 10.1111/CEO.12164
Hong-Wei Pan, Jin-Tang Xu, Jian-Su Chen, Pioglitazone inhibits TGFβ induced keratocyte transformation to myofibroblast and extracellular matrix production Molecular Biology Reports. ,vol. 38, pp. 4501- 4508 ,(2011) , 10.1007/S11033-010-0581-5
Sriniwas Sriram, Daniel J. Gibson, Paulette Robinson, Liya Pi, Sonal Tuli, Alfred S. Lewin, Gregory Schultz, Assessment of anti-scarring therapies in ex vivo organ cultured rabbit corneas. Experimental Eye Research. ,vol. 125, pp. 173- 182 ,(2014) , 10.1016/J.EXER.2014.06.014
Madhavan S. Rajan, David P.S. OʼBrart, Anne Patmore, John Marshall, Cellular effects of mitomycin-C on human corneas after photorefractive keratectomy. Journal of Cataract and Refractive Surgery. ,vol. 32, pp. 1741- 1747 ,(2006) , 10.1016/J.JCRS.2006.05.014
Ryuhei Hayashi, Yuki Ishikawa, Miyuki Ito, Tomofumi Kageyama, Kuniko Takashiba, Tsuyoshi Fujioka, Motokazu Tsujikawa, Hiroyuki Miyoshi, Masayuki Yamato, Yukio Nakamura, Kohji Nishida, Generation of Corneal Epithelial Cells from Induced Pluripotent Stem Cells Derived from Human Dermal Fibroblast and Corneal Limbal Epithelium PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0045435
Krystel R. Huxlin, Holly B. Hindman, Kye-Im Jeon, Jens Bühren, Scott MacRae, Margaret DeMagistris, David Ciufo, Patricia J. Sime, Richard P. Phipps, Topical Rosiglitazone Is an Effective Anti-Scarring Agent in the Cornea PLoS ONE. ,vol. 8, pp. e70785- ,(2013) , 10.1371/JOURNAL.PONE.0070785