Behçet's disease: An immunogenetic perspective

摘要: Behcet's disease (BD) is a chronic and rare multisystemic disorder defined by autoimmunity inflammatory characteristics, manifested ocular lesions, recurrent genital oral ulcers, skin symptoms arthritis as well neurological, intestinal, vascular involvement. Despite the unknown cause of BD, there some strong documentation for immunological, genetic, environmental, infectious factors playing role in pathogenesis BD. While nature genetic variants remains unidentified, many risk are considered to contribute BD susceptibility. Along with human leukocyte antigen gene encoding B*51 (HLA-B*51) areas including major histocompatibility complex class I, genome-wide association studies have recognized numerous other susceptibility genes those interleukin (IL)-10, IL-12 receptor β 2 (IL-12RB2), IL-23 (IL-23R), C-C chemokine 1 gene, signal transducer activator transcription 4 (STAT4), endoplasmic reticulum aminopeptidase (ERAP1), killer cell lectin-like family members (KLRC4-KLRK1). It believed that could be lying between autoimmune autoinflammatory syndromes. The positive responses classical immunosuppressive agents like azathioprine cyclosporine involvement autoantigens initiation main features reflect disorder. In this review, we address recent findings on common cytokines, antibodies immunogenetic