beta(2)-Microglobulin amyloidosis caused spinal cord compression in a long-term haemodialysis patient.

作者: J-R Vignes , S Eimer , R Dupuy , E Donois , D Liguoro

DOI: 10.1038/SJ.SC.3101969

关键词: Intervertebral diskMyelopathyAmyloidosisSpinal cordNeurosurgeryLaminectomySpinal cord compressionCentral nervous system diseaseSurgeryMedicine

摘要: A case report of cervical myelopathy caused by epidural β2-microglobulin (β2m) amyloid deposits in a 50-year-old woman with haemodialysis treatment. Long-term patients end-stage renal disease leads to several complications based on β2m deposits, which can affect, the spine, intervertebral disk, and rare cases, they may compress spinal cord nerves. The objective this is describe clinical radiological follow-up preceding indispensable surgical excision an mass postoperative cervicalgia owing subcondylian bone cyst-associated atlanto-occipital instability also described discussed. Department Neurosurgery A, Hop Pellegrin, Bordeaux, France. We present patient compression. was treated subsequent C2–C3 laminectomy. experienced improvement regression all her neurological symptoms. Histological findings confirm diagnosis deposition. However, 5 years after surgery cysts were still observed required wear minerva. Our confirms that necessary relevant when prognosis discussed, pain major symptom evolution. use high-flux synthetic membranes could decrease blood level early graft only method prevent such complications.

参考文章(16)
Paul D West, David M Colquhoun, TENS in refractory angina pectoris. Three case reports. The Medical Journal of Australia. ,vol. 158, pp. 488- 489 ,(1993) , 10.5694/J.1326-5377.1993.TB137584.X
Etsuji Shiota, Masatoshi Naito, Kuniyoshi Tsuchiya, Surgical therapy for dialysis-related spondyloarthropathy: review of 30 cases. Journal of Spinal Disorders. ,vol. 14, pp. 165- 171 ,(2001) , 10.1097/00002517-200104000-00012
Christian Marcelli, Dominique Pérennou, Catherine Cyteval, Hélène Leray, Jean-Louis Lamarque, Charles Mion, Lucien Simon, Amyloidosis-related cauda equina compression in long-term hemodialysis patients. Three case reports. Spine. ,vol. 21, pp. 381- 385 ,(1996) , 10.1097/00007632-199602010-00026
Daniel Kuntz, Bertrand Naveau, Thomas Bardin, Tilman Drueke, Richard Treves, Antoine Dryll, Destructive spondylarthropathy in hemodialyzed patients. A new syndrome. Arthritis & Rheumatism. ,vol. 27, pp. 369- 375 ,(1984) , 10.1002/ART.1780270402
Kazuya Nokura, Hiroshi Koga, Hiroko Yamamoto, Akihiro Kimura, Hirofumi Tamai, Susumu Yazaki, Nobuo Suzuki, Shigeru Miyazaki, Toshimitsu Niwa, Dialysis-related spinal canal stenosis: a clinicopathological study on amyloid deposition and its AGE modification. Journal of the Neurological Sciences. ,vol. 178, pp. 114- 123 ,(2000) , 10.1016/S0022-510X(00)00377-4
Farhad R. Danesh, Jens Klinkmann, Hidejiro Yokoo, Peter Ivanovich, Fatal cervical spondyloarthropathy in a hemodialysis patient with systemic deposition of β-microglobulin amyloid American Journal of Kidney Diseases. ,vol. 33, pp. 563- 566 ,(1999) , 10.1016/S0272-6386(99)70195-2
A. Korzets, R. Gepstein, Y. Ori, A. Chagnac, T. Weinstein, M. Herman, D. Zevin, U. Gafter, Quadriparesis and faecal incontinence in a long-term haemodialysis patient Nephrology Dialysis Transplantation. ,vol. 12, pp. 224- 225 ,(1997) , 10.1093/NDT/12.1.224
Somnath Nair, John Vender, Thomas M. McCormack, Perry Black, Renal osteodystrophy of the cervical spine: neurosurgical implications. Neurosurgery. ,vol. 33, pp. 349- 355 ,(1993) , 10.1227/00006123-199309000-00001
Karl M. Koch, Dialysis-related amyloidosis Kidney International. ,vol. 41, pp. 1416- 1429 ,(1992) , 10.1038/KI.1992.207
George S. Davidson, Walter J. Montanera, J. F. Ross Fleming, Fred Gentili, Amyloid Destructive Spondyloarthropathy Causing Cord Compression: Related to Chronic Renal Failure and Dialysis Neurosurgery. ,vol. 33, pp. 519- 522 ,(1993) , 10.1227/00006123-199309000-00026