Tumour biological features of BRCA1-induced breast and ovarian cancer.
作者： Ó.T. Jóhannsson , I. Idvall , C. Anderson , Å. Borg , R.B. Barkardóttir
DOI: 10.1016/S0959-8049(97)89007-7
关键词: Ovarian cancer 、 Ovarian carcinoma 、 Carcinogenesis 、 Cancer 、 Population 、 Cancer research 、 Biology 、 Progesterone receptor 、 Breast carcinoma 、 Pathology 、 CA15-3
摘要: BRCA1 mutations, although implicated in disease predisposition a major part of the hereditary breast cancer population, do not seem to be crucially involved tumorigenesis sporadic and ovarian cancers. This suggests that tumours arising mutation carriers may differ from negative genetic biological features, as well clinical behaviour. Prior analysis, 79 19 57 breast-ovarian families, 170 comparison group stage II cancers were studied with regard histopathological features; immunohistochemistry [c-erbB-2, p53, oestrogen receptor (ER) progesterone (PR)], DNA flow cytometry S-phase fraction. mutations found 40 15 tumours. The positive significantly more often ductal type, histological grade III manifested heavy lymphocyte infiltration. Additionally, compared tumours, ER, PgR c-erbB-2 negative. Furthermore, they non-diploid, being characterised by higher fraction values. These results suggest BRCA1-induced manifest distinct tumour features importance.
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