Tudor-SN Regulates Milk Synthesis and Proliferation of Bovine Mammary Epithelial Cells
作者： Jinxia Ao , Chengjie Wei , Yu Si , Chaochao Luo , Wei Lv
关键词: Nuclear protein 、 Molecular biology 、 Gene silencing 、 Amino acid 、 Biology 、 Downregulation and upregulation 、 Transcriptional regulation 、 Cell growth 、 NFKB1 、 Signal transduction
摘要: Tudor staphylococcal nuclease (Tudor-SN) is a highly conserved and ubiquitously expressed multifunctional protein, related to multiple diverse cell type- species-specific cellular processes. Studies have shown that Tudor-SN mainly in secretory cells, however knowledge of its role limited. In our previous work, we found the protein level was upregulated nucleus bovine mammary epithelial cells (BMEC). this study, assessed milk synthesis proliferation BMEC. We exploited gene overexpression silencing methods, positively regulates via Stat5a activation. Both amino acids (methionine) estrogen triggered NFκB1 bind promoters Stat5a, enhanced nuclear localization p-Stat5a. Taken together, these results suggest key transcriptional regulation BMEC under stimulation hormones.
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Michael J. Waters, The growth hormone receptor Growth Hormone & Igf Research. ,vol. 28, pp. 6- 10 ,(2016) , 10.1016/J.GHIR.2015.06.001
Enara Arretxe, Sandra Armengol, Sarai Mula, Yolanda Chico, Begoña Ochoa, María José Martínez, Profiling of promoter occupancy by the SND1 transcriptional coactivator identifies downstream glycerolipid metabolic genes involved in TNFα response in human hepatoma cells Nucleic Acids Research. ,vol. 43, pp. 10673- 10688 ,(2015) , 10.1093/NAR/GKV858
Limin Lu, Xuejun Gao, Qingzhang Li, Jianguo Huang, Rong Liu, Huiming Li, Comparative phosphoproteomics analysis of the effects of L-methionine on dairy cow mammary epithelial cells Canadian Journal of Animal Science. ,(2012) , 10.4141/CJAS2012-063
Joel D Leverson, Päivi J Koskinen, Frank C Orrico, Eeva-Marja Rainio, Katriina J Jalkanen, Ajeeta B Dash, Robert N Eisenman, Scott A Ness, Pim-1 Kinase and p100 Cooperate to Enhance c-Myb Activity Molecular Cell. ,vol. 2, pp. 417- 425 ,(1998) , 10.1016/S1097-2765(00)80141-0
Olatz Fresnedo, Miguel López De Heredia, María José Martínez, Susana Cristóbal, María Teresa Rejas, José M Cuezva, Begoña Ochoa, Immunolocalization of a novel cholesteryl ester hydrolase in the endoplasmic reticulum of murine and human hepatocytes. Hepatology. ,vol. 33, pp. 662- 667 ,(2001) , 10.1053/JHEP.2001.22763
Yu-Ling Huang, Feng Zhao, Chao-Chao Luo, Xia Zhang, Yu Si, Zhe Sun, Li Zhang, Qing-Zhang Li, Xue-Jun Gao, SOCS3-Mediated Blockade Reveals Major Contribution of JAK2/STAT5 Signaling Pathway to Lactation and Proliferation of Dairy Cow Mammary Epithelial Cells in Vitro Molecules. ,vol. 18, pp. 12987- 13002 ,(2013) , 10.3390/MOLECULES181012987
Juha Saarikettu, Vladimir Ovod, Milka Vuoksio, Juha Grönholm, Jie Yang, Olli Silvennoinen, None, Monoclonal Antibodies Against Human Tudor-SN Hybridoma. ,vol. 29, pp. 231- 236 ,(2010) , 10.1089/HYB.2009.0114
P. Lacasse, V. Lollivier, F. Dessauge, R.M. Bruckmaier, S. Ollier, M. Boutinaud, New developments on the galactopoietic role of prolactin in dairy ruminants Domestic Animal Endocrinology. ,vol. 43, pp. 154- 160 ,(2012) , 10.1016/J.DOMANIEND.2011.12.007
Douglas A Harrison, The JAK-STAT Pathway Molecular Immunology. ,vol. 37, pp. 1- 11 ,(2000) , 10.1016/S0161-5890(00)00018-3
Xi Qian, Feng-Qi Zhao, Current major advances in the regulation of milk protein gene expression. Critical Reviews in Eukaryotic Gene Expression. ,vol. 24, pp. 357- 378 ,(2014) , 10.1615/CRITREVEUKARYOTGENEEXPR.2014012215