SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
作者： Hiart Navarro-Imaz , Yuri Rueda , Olatz Fresnedo
DOI: 10.1016/J.BBALIP.2016.05.011
关键词: Biology 、 Liver X receptor 、 Cancer research 、 Nuclear protein 、 Lipid metabolism 、 Cholesterol 、 SND1 、 Sterol regulatory element-binding protein 2 、 Homeostasis 、 Cancer cell 、 Cell biology 、 Molecular biology
摘要: SND1 is a multifunctional protein participating, among others, in gene transcription and mRNA metabolism. overexpressed cancer cells promotes viability tumourigenicity of hepatocellular carcinoma cells. This study shows that cholesterol synthesis increased SND1-overexpressing hepatoma Neither newly synthesised nor extracellularly supplied are able to suppress this increase; however, inhibition esterification reverted the activated state sterol-regulatory element-binding 2 (SREBP2) cholesterogenesis. These results highlight as potential regulator cellular distribution homeostasis cells, support rationale for therapeutic use molecules influence management when overexpressed.
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