Alterations in Fetal Heart Rate and ECG Correlated to Glycogen, Creatine Phosphate and ATP Levels during Graded Hypoxia

摘要: The depletion of glycogen, creatine phosphate and ATP in the fetal heart, liver brain was studied 40 mature guinea pig fetuses acutely exteriorized submitted to a graded hypoxia. A strong linear correlation found between an ECG scoring system, taking severity ST-T changes into account, heart glycogen creatine-P. unaffected until almost depleted (25 % initial value). At this point, were also severely affected. Bradycardia (AV-block, type II) strongly correlated failing myocardial metabolism. It is concluded that pattern could be regarded as sign glycolysis early hypoxic stress.