Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis
作者： Haruhiko Fuwa
DOI: 10.1039/D1QO00481F
关键词: Nuclear magnetic resonance spectroscopy 、 Structure analysis 、 Chemistry 、 Lobatamide C 、 Polyketide 、 Callyspongiolide 、 Chemical synthesis 、 Computational chemistry
摘要: Despite significant advances in NMR spectroscopy, structure elucidation of natural products, especially stereochemically complex polyketides with limited availability, is still a challenging task for chemists. Recent examples determination, correction and disproof structurally marine polyketide macrolides by chemical synthesis, namely lobatamide C, reidispongiolide A, callyspongiolide, palmerolide muironolide iriomoteolide-2a, chagosensine cases, are summarized this review, which highlights the scope limitation current NMR-based analysis vital role synthesis elucidation.
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