Irradiation of Mixed Beam and Design of Spread-Out Bragg Peak for Heavy-Ion Radiotherapy
作者： Tatsuaki Kanai , Yoshiya Furusawa , Kumiko Fukutsu , Hiromi Itsukaichi , Kiyomi Eguchi-Kasai
DOI: 10.2307/3579446
关键词: Linear energy transfer 、 Atomic physics 、 Bragg's law 、 Carbon Ion Radiotherapy 、 Bragg peak 、 Cell killing 、 Optics 、 Sobp 、 Heavy Ion Radiotherapy 、 Irradiation 、 Chemistry
摘要: Data on cellular inactivation resulting from mixed irradiation with charged-particle beams of different linear energy transfer (LET) are needed to design a spread-out Bragg peak (SOBP) for heavy-ion radiotherapy. The present study was designed the relationship between physical and biological (cell killing) properties by using monoenergetic ${}^{3}{\rm He},{}^{4}{\rm He}$ and12 C ions (12 18.5 MeV/nucleon) attempt apply experimental data in SOBP (3 cm width) 135 MeV/nucleon carbon beam. Experimental studies measurements sequentially combined were carried out establish close LET cell inactivation. results indicated that dose-cell survival high- low-LET could be described linear-quadratic (LQ) model, which new coefficients α β obtained in...
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