A specific epitope of protein inhibitor of activated STAT3 is responsible for the induction of apoptosis in rat transformed mast cells.
作者： Zohar Yagil , Gillian Kay , Hovav Nechushtan , Ehud Razin
关键词: Microphthalmia-associated transcription factor 、 Apoptosis 、 Epitope 、 Cell cycle 、 Molecular biology 、 Transcription factor 、 Phenotype 、 STAT3 、 Biology 、 In vivo
摘要: Protein inhibitor of activated STAT3 (PIAS3) functions in vivo as a key molecule suppressing the transcriptional activity both microphthalmia transcription factor (MITF) and STAT3, two factors that play major role development, phenotypic expression, survival mast cells melanocytes. In present study we have investigated played by PIAS3 regulation cell cycle We characterized biological 23-aa domain derived from induces apoptosis these inhibiting MITF STAT3. This peptide could serve beginning an depth for development inhibitors
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