Chapter 5 Biosynthesis 3. Biosynthesis of O-Glycans of the N-Acetylgalactosamine-α-Ser/Thr Linkage Type
作者： Inka Brockhausen
DOI: 10.1016/S0167-7306(08)60593-1
关键词: Oligosaccharide 、 Sialic acid 、 Biology 、 Carbohydrate 、 Biochemistry 、 Fucose 、 Biosynthesis 、 Glycoprotein 、 N-Acetylgalactosamine 、 Sulfation
摘要: Publisher Summary This chapter discusses the biosynthesis of Oligosaccharides (O-glycans) N-acetylgalactosamine- α-Ser/Thr linkage type. The synthesis frame-work oligosaccharide chains regulates expression functional terminal carbohydrate structures. Thus, a control on early steps biosynthetic pathways proves to have great impact structures, properties, and biological functions O-glycans. O-Glycosylation commonly changes during development, differentiation, growth, in disease. In addition, various tissues species express characteristic O-glycans associated with functions. Genetic defects are rare; possibly because development multicellular organism is dependent interactions cellular carbohydrate.The sugars found GalNAc, Gal, GlcNAc, sialic acid, fucose. GlcNAc GalNAc may be sulfated contribute acid acidity many mammalian non-mammalian soluble membrane-bound glycoproteins, proteoglycans.
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