Detection of Cardiac Toxicity Due to Cancer Treatment: Role of Cardiac MRI

作者: Nandini M. Meyersohn , Amit Pursnani , Tomas G. Neilan

DOI: 10.1007/S11936-015-0396-8

关键词: Coronary artery diseaseRadiologyMedicineHeart failureCancerRadiation therapyCardiotoxicityAnthracyclineInternal medicineRestrictive cardiomyopathyCardiologyEjection fraction

摘要: Common cancer treatments including anthracycline-based chemotherapy, tyrosine kinase inhibitors, and thoracic radiation therapy can result in short- long-term cardiovascular complications with a significant impact on morbidity mortality. Anthracycline-based chemotherapy inhibitors are associated left ventricular systolic dysfunction heart failure. Radiation is restrictive cardiomyopathy, coronary artery disease, as well pericardial valvular disease. The current standard surveillance of oncology patients for cardiotoxicity involves echocardiography, radionuclide cardiac blood pool imaging, magnetic resonance (CMR) imaging. CMR be used to evaluate structure function, which important management decisions prevent further injury. In whom imaging demonstrates drop function or without symptoms, the use an appropriate next step evaluation due accuracy reproducibility measurements volumes combined additive information provided by tissue characterization through myocardial edema fibrosis, although clinical applications these latter yet unclear. Overall, detection early since therapeutic response improved prompt initiation medical treatment.

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