Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target

摘要: Colorectal cancer is one of the leading causes tumor-related morbidity and mortality worldwide. While mechanisms underlying this disease have been elucidated over past two decades, these molecular insights failed to translate into efficacious therapy. The oncogenomic view suggests that terminal transformation reflects sequential corruption signal transduction circuits regulating key homeostatic mechanisms, whose multiplicity underlies therapeutic resistance most tumors interventions targeting individual pathways. Conversely, paucity mechanistic proximal pathophysiological processes initiate amplify oncogenic preceding accumulation mutations impedes development effective prevention In context, guanylyl cyclase C (GCC), intestinal receptor for paracrine hormones guanylin uroguanylin, early loss characterizes colorectal transformation, has emerged as a component lineag...