Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function.
作者： C. Sakanaka , P. Leong , L. Xu , S. D. Harrison , L. T. Williams
关键词:
摘要: Wnt and its intracellular effector β-catenin regulate developmental oncogenic processes. Using expression cloning to identify novel components of the pathway, we isolated casein kinase Iɛ (CKIɛ). CKIɛ mimicked in inducing a secondary axis Xenopus, stabilizing β-catenin, stimulating gene transcription cells. Inhibition endogenous by kinase-defective or antisense-oligonucleotides attenuated signaling. was complex with axin other downstream including Dishevelled. appears be positive regulator pathway link between upstream signals complexes that β-catenin.
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sci-hub.se 参考文章(26)
Stefan D. Gross, Richard A. Anderson, Casein Kinase I Cellular Signalling. ,vol. 10, pp. 699- 711 ,(1998) , 10.1016/S0898-6568(98)00042-4
J. Behrens, Functional Interaction of an Axin Homolog, Conductin, with -Catenin, APC, and GSK3 Science. ,vol. 280, pp. 596- 599 ,(1998) , 10.1126/SCIENCE.280.5363.596
Barry M. Gumbiner, Carcinogenesis: A balance between β-catenin and APC Current Biology. ,vol. 7, pp. R443- R446 ,(1997) , 10.1016/S0960-9822(06)00214-4
P. J. Morin, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. ,vol. 275, pp. 1787- 1790 ,(1997) , 10.1126/SCIENCE.275.5307.1787
Norbert Perrimon, The genetic basis of patterned baldness in Drosophila Cell. ,vol. 76, pp. 781- 784 ,(1994) , 10.1016/0092-8674(94)90351-4
K. M. Cadigan, R. Nusse, Wnt signaling: a common theme in animal development Genes & Development. ,vol. 11, pp. 3286- 3305 ,(1997) , 10.1101/GAD.11.24.3286
Jürgen Behrens, Jens P. von Kries, Michael Kühl, Laurakay Bruhn, Doris Wedlich, Rudolf Grosschedl, Walter Birchmeier, Functional interaction of β-catenin with the transcription factor LEF-1 Nature. ,vol. 382, pp. 638- 642 ,(1996) , 10.1038/382638A0
Frank van Leeuwen, Cynthia Harryman Samos, Roel Nusse, Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells Nature. ,vol. 368, pp. 342- 344 ,(1994) , 10.1038/368342A0
Karl Willert, Roel Nusse, β-catenin: a key mediator of Wnt signaling Current Opinion in Genetics & Development. ,vol. 8, pp. 95- 102 ,(1998) , 10.1016/S0959-437X(98)80068-3
Randall T Moon, Jeffrey D Brown, Monica Torres, WNTs modulate cell fate and behavior during vertebrate development Trends in Genetics. ,vol. 13, pp. 157- 162 ,(1997) , 10.1016/S0168-9525(97)01093-7