Adjuvant Radiation is Associated with Improved Survival for Select Patients with Non-metastatic Adrenocortical Carcinoma

摘要: Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy for which surgery the mainstay of treatment adjuvant radiation infrequently employed; however, small, single-institution series suggest may improve outcomes. All patients with non-metastatic ACC treated either alone or followed by were identified in 2004–2013 National Cancer Database. Factors associated receipt impact on survival determined multivariable analysis. Of 1184 patients, 171 (14.4%) received radiation. Patient demographics similar between two groups, but those receiving more likely to have had positive margins following (37.4 vs. 14.6%; p < 0.001), evidence vascular invasion (14.0 5.1%; p = 0.05), receive concurrent chemotherapy (57.3 28.8%; p < 0.001). After adjustment tumor other factors, only was an increased likelihood (odds ratio 3.84, 95% confidence interval [CI] 1.95–7.56). Radiation therapy did not confer difference median overall general cohort. However, margins, 40% decreased yearly risk death after (hazard 0.60, CI 0.40–0.92; p = 0.02). This advantage evident traditional high-risk features. Adjuvant appears decrease surgical resection, small percentage are currently Multidisciplinary should be considered these patients.