Tolerability and efficacy of dorzolamide versus acetazolamide added to timolol.

摘要: Purpose: Evaluate the safety and efficacy of dorzolamide versus acetazolamide when added to once daily 0.5% timolol maleate ophthalmic gel forming solution (timolol gel). Methods: This was a randomized, double-masked, multicenter, active-controlled, parallel group study 215 patients with open-angle glaucoma or ocular hypertension. Following two-week treatment period gel, IOP ≥ 22 mm Hg who tolerated one week 250-mg q.i.d. either were randomized 2% three times for 12 weeks. Results: In 155 (dorzolamide, N = 80, acetazolamide, 75), compared dorzolamide, had statistically greater number systemic adverse events (dorzolamide 50%, 75%, p 0.001), associated carbonic anhydrase inhibitor (CAI) therapy 26%, 53%, < 0.001) discontinuations due CAI experiences 8%, 24%, 0...