Monodisperse, sequence-defined macromolecules as a tool to evaluate the limits of ring-closing metathesis

摘要: Sequence-defined macromolecules of uniform size unlock the door to many new applications in polymer chemistry, such as structure/property or structure/activity relationship investigations, which cannot be conducted accurately, if investigated exhibit dispersity. We herein demonstrate a first example by reporting efficient and template-free synthesis monodisperse, sequence-defined cyclic oligomers that are significantly larger than conventional large macrocycles (here >150 backbone atoms). Linear monodisperse precursors were utilized evaluate limits ring-closing metathesis (RCM), manifesting clear trends depending on ring introduced side chains. Furthermore, this work is architecture other linear macromolecules.