A novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides
作者： Steven A. Kates , Nuria A. Solé , Charles R. Johnson , Derek Hudson , George Barany
DOI: 10.1016/0040-4039(93)85003-F
关键词: Peptide synthesis 、 Solid-phase synthesis 、 Cyclic peptide 、 Chemistry 、 Palladium 、 Stereochemistry
摘要: Abstract Head-to-tail cyclic peptides are made by an efficient three-dimensional orthogonal solid-phase strategy (Fmoc/tBu/allyl), featuring side-chain anchoring to PAC or PAL supports, selective palladium (O)-catalyzed allyl removal, and resin-bound cyclization mediated BOP/HOBt/DIEA.
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