Mechanism of action of cyclic antimicrobial peptides
作者： Anna Díaz i Cirac
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摘要: This PhD thesis is the result of combination experimental and computational techniques with aim understanding mechanism action de novo cyclic decapeptides high antimicrobial activity. By influence replacement phenylalanine for tryptophan residue in their activity was tested stability human serum also analyzed, order to evaluate potential therapeutic application as antitumor agents. On other hand, interaction amongst peptide BPC194 c(KKLKKFKKLQ), best candidate from whole library peptides, a model anionic membrane simulated. The results showed structure-function relationship derived stable conformation peptides involved permeabilization. As result, rational design performed being BPC490 compared active original library.
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