Effect of Theophylline on Ischemically Induced Hippocampal Damage in Mongolian Gerbils: A Behavioral and Histopathological Study

摘要: We investigated the influence of adenosine antagonist theophylline on degree hippocampal cell damage in Mongolian gerbil following brief periods forebrain ischemia. Male gerbils were randomly divided into nine groups. Ten minutes before surgery, four groups, which later subjected to 1, 2, 3, or 5 min bilateral carotid occlusion under halothane anesthesia, received (30 mg/kg, p.o.). Four groups served as nontreated ischemic controls; ninth group was used measure serum concentration. Neurological symptoms classified by using a behavioral score. Fourteen days after ischemia, brains removed, and hippocampus histologically examined “blind” for CA1 sector, expressed semiquantitative histopathological There no histological abnormalities either control with 1 With increasing duration neurological sy...