Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocampus.

摘要: An unusual, delayed neuronal death (DND) has been noticed in the hippocampus of Mongolian gerbil following brief ischemia (Kirino 1982). On day 1 5–10min ischemia, light microscopy showed CA1 pyramidal cells unchanged. 2, massive growth membranous cytoplasmic organelles instead overt cellular disintegration. These neurons were destroyed extensively by 4 after ischemic insult. Following longer (20–30min), however, changes appeared faster and resembled wellcharacterized cell change (ICC). To further clarify differences between ICC DND, gerbils submitted to transient 5–30min ischemia. They perfusion-fixed a given survival period then processed for electron microscopy. specimens slow with cisterns endoplasmic reticulum (ER). In some neurons, cytoplasm was shrunken darkly stained, but they also displayed accumulation ER cisterns. Occasionally, demonstrated highly dark perikarya, no different than ICC. results indicate that DND seems be typical disease process sector severer insult makes more similar occur when are damaged so severely cannot react proliferous activity.