Effect of the hypocholesterolemic drug AY9944 on developing central nervous system of rats: alteration of endoplasmic reticulum in oligodendroglia.

作者: Kinuko Suzuki , Joy C. Zagoren

DOI: 10.1007/BF01103795

关键词: BiologyBiochemistryNeurogliaMembraneCell biologyCytoplasmRibosomeNervous systemGolgi apparatusCentral nervous systemEndoplasmic reticulum

摘要: Unusual alterations of the endoplasmic reticulum were seen in oligodendroglia young rats treated with AY9944. They consisted of: 1. random proliferation membranes within cytoplasm, some them attached ribosomes; 2. multi-layers paired connected to cisternae rough which encircled cytoplasm as a whole or focally; 3. formation numerous small whorls about 0.5 μm diameter are made up two fused reticulum.

参考文章(46)
Y. Kikkawa, K. Suzuki, Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone). American Journal of Pathology. ,vol. 54, pp. 307- 325 ,(1969)
HENRY S. SCHUTTA, LOIS JOHNSON, Bilirubin encephalopathy in the Gunn rat: a fine structure study of the cerebellar cortex. Journal of Neuropathology and Experimental Neurology. ,vol. 26, pp. 377- 396 ,(1967) , 10.1097/00005072-196707000-00003
I. Carr, Jean Carr, Membranous whorls in the testicular interstitial cell The Anatomical Record. ,vol. 144, pp. 143- 147 ,(1962) , 10.1002/AR.1091440209
M. Dubois-Dalcq, R. Menu, M. Buyse, Influence of fatty acids on fine structure of cultured neurons. An experimental approach to Refsum's disease. Journal of Neuropathology and Experimental Neurology. ,vol. 31, pp. 645- 667 ,(1972) , 10.1097/00005072-197210000-00008
James R. Brawer, The role of the arcuate nucleus in the brain-pituitary-gonad axis. The Journal of Comparative Neurology. ,vol. 143, pp. 411- 445 ,(1971) , 10.1002/CNE.901430403
Lawrence Herman, Patrick J. Fitzgerald, Restitution of pancreatic acinar cells following ethionine. Journal of Cell Biology. ,vol. 12, pp. 297- 312 ,(1962) , 10.1083/JCB.12.2.297
Bojan Flaks, Formation of membrane-glycogen arrays in rat hepatoma cells. Journal of Cell Biology. ,vol. 36, pp. 410- 414 ,(1968) , 10.1083/JCB.36.2.410