Protein synthesis in the cat brain after prolonged cerebral ischemia
作者： P. Kleihues , K.-A. Hossmann
DOI: 10.1016/0006-8993(71)90484-7
关键词: Electroencephalography 、 Medicine 、 Distribution (pharmacology) 、 Amino acid 、 Anesthesia 、 CATS 、 Stimulation 、 Internal medicine 、 Ischemia 、 Protein biosynthesis 、 Endocrinology 、 Polysome
摘要: Complete cerebral ischemia for 30 min was produced in normothermic cats by clamping the innominate and left subclavian arteries simultaneous lowering of systemic blood pressure. Recovery neuronal function after ascertained recording EEG pyramidal response to electrical stimulation sensorimotor cortex. The incorporation [14Clabeled amino acids into brain proteins determined at different time intervals ischemia. Specific radioactivity approached control values within 4 h. At same time, however, specific total free pool considerably increased. Sucrose density gradient analysis electron microscopic studies revealed a distribution polysomes monosomes during similar that animals, but marked disaggregation observed postischemic recovery phase. The data are discussed with regard possible mechanism inhibition protein synthesis
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