Nuclear Cell Regulatory Mechanism in Cerebral Ischemia and Anoxia

摘要: In cerebral ischemia and anoxia, the depletion of oxygen supply promptly results in a rapid decline high energy source, such as adenosine triphosphate or creatine phosphate. However, effect reduction state on transcription step within nuclear cell regulatory mechanism translation at polyribosomal level has not been well investigated. Since prolonged anoxia result irreversible cellular damage leading to infarction, disturbance macro-molecular may play an important role reversibility these pathophysiological conditions. past several years, effort our laboratory focused effects steps, comparison anoxia. For purposes, we have utilized gerbils experimental model for rabbits vitro this communication, protein synthesis with brain slices vitro, polypeptide isolated microsomes, DNA-dependent RNA polymerase activity phosphorylation chromatin will be compared