Tetramethylpyrazine inhibits CoCl2-induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways
作者： Dongsheng Guan , Yufei Su , Yingxia Li , Chuanjie Wu , Yi Meng
DOI: 10.1111/JNC.13161
关键词: Oxidative stress 、 Neuroprotection 、 GCLC 、 NADPH oxidase 、 Reactive oxygen species 、 Tetramethylpyrazine 、 Apoptosis 、 Chemistry 、 Pharmacology 、 Neurotoxicity
摘要: … HIF1α/NOX2 pathway was involved, at least partly, in its antioxidant role in CoCl 2 -treated cells (Fig. 6f). Moreover, over-expression of HIF1α … that inhibition of HIF1α/NOX2 pathway was …
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