Isolation, acid proteinase secretion, and experimental pathogenicity of Candida parapsilosis from outpatients with vaginitis.

摘要: Candida parapsilosis was isolated from the vaginas of several nonpregnant, nondiabetic, mostly premenopausal outpatients who presented characteristic signs and symptoms a frank vulvovaginal candidiasis (heavy discharge with cottage cheese appearance intense itching, or without vulvar erythema dyspareunia). All isolates conformed morphologically, biochemically, serologically to standard description species. They showed high acid proteinase-secretory activity in vitro were appreciably pathogenic for cyclophosphamide-immunodepressed mice. Some also tested their vaginopathic potential ovariectomized rats under estradiol administration. In all cases, rat vagina colonized by C. an extent duration not different those caused isolate albicans. Periodic acid-Schiff-stained vaginal smears taken at intervals during experimental infection yeasts adhering exfoliated epithelial cells vagina. Overall, these results emphasize proteolytic suggest that this fungus may be agent clinical vaginitis. Images