Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure.

摘要: Thoracic Spinal Cord Stimulation. Background: Prior experimental studies show that thoracic spinal cord stimulation (SCS) improves left ventricular (LV) ejection fraction (LVEF). The mechanism of this improvement in the LV contractile function after SCS and its effects on myocardial oxygen consumption remains unknown. Methods Results: We performed (T1-T2 level) followed by 4 weeks rapid pacing 9 adult pigs with ischemic heart failure (HF) induced infarction (MI). At 24 hours off-pacing, detailed echocardiogram invasive hemodynamic assessment were to determine consumption. Serum norepinephrine level was measured before SCS. 2 occasions for 15 minutes, 30 minutes apart (recovery) 50 Hz frequency (pulse width 0.2 millisecond, 90% motor threshold at output). Echocardiogram revealed significant decrease LVEF (33.8 ± 1.8% vs 66.5 1.7%, P < 0.01) induction MI HF. Compared HF, acute significantly increased +dP/dt (all 0.05). Withdrawal during recovery decreased +dP/dt, but not again repeated Myocardial also compared HF (P = 0.006) without any change serum 0.9). Speckle tracking imaging showed global regional circumferential strains over infarcted mid apical regions, time peak strain lateral posterior wall SCS, degree intraventricular dyssynchrony 0.05). Conclusions: In a porcine model improved dyssynchrony, elevation level. (J Cardiovasc Electrophysiol, Vol. 23, pp. 534-540, May 2012)