Influence of Microbial Metabolites on the Nonspecific Permeability of Mitochondrial Membranes under Conditions of Acidosis and Loading with Calcium and Iron Ions.
作者： Andrei Olenin , Nadezhda Fedotcheva , Natalia Beloborodova
DOI: 10.3390/BIOMEDICINES9050558
关键词: Biochemistry 、 Permeability (electromagnetism) 、 Chemistry 、 MPTP 、 Membrane 、 Acidosis 、 Calcium 、 Inner mitochondrial membrane 、 Mitochondrial permeability transition pore 、 Mitochondrion
摘要: Mitochondrial dysfunction is currently considered one of the main causes multiple organ failure in chronic inflammation and sepsis. The participation microbial metabolites disorders bioenergetic processes mitochondria has been revealed, but their influence on mitochondrial membrane permeability not yet studied. We tested various groups metabolites, including indolic phenolic acids, trimethylamine-N-oxide (TMAO) acetyl phosphate (AcP), nonspecific membranes under conditions acidosis, imbalance calcium ions excess free iron, which are inherent Changes parameters calcium-induced opening transition pore (MPTP) iron-activated swelling rat liver were evaluated. most active indole-3-carboxylic acid (ICA) benzoic (BA), activated MPTP all conditions. AcP showed opposite effect induction opening, increasing threshold concentration by 1.5 times, while TMAO only acidification. All redox-dependent effects suppressed lipid radical scavenger butyl-hydroxytoluene (BHT), indicates these activation peroxidation. Thus, can directly affect membranes, if an iron created pathological state.
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