Teratogen update: Ergot and ergotamine

摘要: Ergotamine is a purified ergot alkaloid that has been suspected of being teratogenicAnimal data have shown effects mainly at doses toxic to the mother. Clinical reports in humans anecdotal, but many malformations are consistent with vascular injury. However, epidemiologic studies not any clear increase among exposed infants. This may reflect limited exposure and toxicity when used episodically. Ergot which can result severe vasospasm does spare fetus or mother ergotamine should be considered without risk. avoided pregnancy, counselling woman an focus on possible exposure. © 1995 WiIey-Liss, Inc.