Teratological experiments with ergotamine in mice, rats, and rabbits

摘要: Pregnant mice, rats, and rabbits were treated orally with ergotamine during midgestation. In doses that affected maternal weight gain treatment, produced an increase in prenatal mortality rats evidence of fetal retardation all three species. The results are discussed connection the vasoconstrictive action ergotamine. A uterotonic effect may also be involved mechanism action. No specific teratogenic activity was detected any