Direct vascular effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
作者： Teruaki Wajima , Shigeki Makita , Kenichi Oshima
DOI: 10.1111/J.1440-1681.2003.03932.X
关键词: Endocrinology 、 Coenzyme A 、 Growth factor 、 Platelet-derived growth factor receptor 、 Endothelial stem cell 、 Biology 、 Xanthine 、 Reductase 、 Superoxide 、 Molecular biology 、 Internal medicine 、 Xanthine oxidase
摘要: Summary 1. We have examined the effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on porcine endothelial cell (EC) injury induced by xanthine (X)/xanthine oxidase (XO), source superoxide anion. Furthermore, HR780 platelet-derived growth factor (PDGF)-induced migration and fetal calf serum (FCS)-induced proliferation rabbit smooth muscle cells (SMC) were investigated. 2. Probucol, at 10 µmol/L, significantly (P < 0.001) completely suppressed lactate dehydrogenase leakage X/XO. At (P = 0.010) inhibited X/XO-induced EC injury. 3. HR780 dose-dependently PDGF-induced SMC FCS-induced proliferation. The addition mevalonate abolished inhibitory effect Another HMG-CoA simvastatin (0.1–100 µmol/L), also responses as potently HR780. In contrast, pravastatin (0.1–100 µmol/L) did not show any effects. 4. This in vitro study provides first evidence that protects vascular endothelium from oxidant stress inhibits SMC.
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