Can amyotrophic lateral sclerosis patients with respiratory insufficiency exercise

摘要: The authors have shown in a recent paper that survival with amyotrophic lateral sclerosis (ALS) can be increased by the use of non-invasive methods assisted ventilation (Bipap). However, progression muscle weakness was not affected and quality life positively enhanced. In ALS, reduced physical activity may partially secondary to alveolar hypoventilation syndrome. This leads deconditioning ALS/motor neuron disease (ALS/MND) patients. decided investigate possibility reducing motor decline exercising these patients anaerobic threshold, but simultaneously compensating respiratory insufficiency Bipap STD. We conducted controlled single blind study, eight consecutive ALS/MND used control group 12 were all evaluated during 1 year period. Respiratory function tests (RFT) performed at entry then 6 month intervals. Barthel, Functional Independent Mobility scale (FIM) Spinal Bulbar Norris scores recorded every 3 months. There significant difference between two groups respect FIM (P<0.03), Barthel (P<0.8). A slower clinical course (Spinal score P<0.02) slope RFT (P<0.008) observed treated group, suggesting exercise beneficial ALS once is peripheral oxygenation.