Rationale and Approaches to Constructing Preerythrocytic Malaria Vaccines

摘要: Parasites belonging to the genus Plasmodium are causative agent for malaria. This disease is primarily found in tropics and conservatively estimated cause 200–300 million new cases each year with approximately 2 deaths resulting. The parasite has a complex life cycle which initiated host when an anopheline mosquito injects sporozoite stage as it takes blood meal. sporozoites travel through circulation liver where they invade hepatocytes. Once hepatocyte undergoes of differentiation division length varies species, ultimately producing many thousands merozoites reenter on rupture hepatocyte. These liver-stage red cells again multiply. After 48–72 h cell ruptures, releasing 6–30 can then other cells. Some parasites differentiate into male female gametocytes, ingested by combine form zygote further development produce that be inoculated another host, thereby repeating cycle.