Current considerations in vaccination of humans against malaria: Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria

摘要: Three human volunteers were successfully protected against sporozoite challenge by immunization with attenuated sporozoites of the Tamenie strain Plasmodium falciparum from Ethiopia. The immunizing exposing infected Anopheles stephensi mosquitos to X-rays at a dose least 120 Gy (12 000 rad). These irradiated, allowed feed upon volunteers, thereby inoculating into their blood stream. During 10- 38-week period immunization, exposed 6-8 times, irregular intervals, total 440-987 irradiated mosquitos. Protection nonirradiated lasted for 8 weeks, but not 16 after last sporozoites. By contrast, who 200 or fewer on 2-4 occasions challenge. Immunization sufficient number chloroquine-sensitive Ethiopia also chloroquine-resistant Marks P. Viet Nam. results obtained in these studies suggest that may be useful method protecting small groups nonimmune individuals living endemic areas. findings should encourage further efforts develop vaccine malaria.