The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
作者： Y.-P. Rong , G. Bultynck , A. S. Aromolaran , F. Zhong , J. B. Parys
关键词: Calcium signaling 、 Peptide sequence 、 Cytochrome c 、 Cell biology 、 Biology 、 Receptor 、 Inositol trisphosphate receptor 、 Programmed cell death 、 Immunoprecipitation 、 Endoplasmic reticulum
摘要: Although the presence of a BH4 domain distinguishes the antiapoptotic protein Bcl-2 from its proapoptotic relatives, little is known about its function. BH4 deletion converts Bcl-2 into a …
harvard.edu
sci-hub.se 参考文章(48)
Michael J. Berridge, Peter Lipp, Martin D. Bootman, The versatility and universality of calcium signalling Nature Reviews Molecular Cell Biology. ,vol. 1, pp. 11- 21 ,(2000) , 10.1038/35036035
Shigeomi Shimizu, Masashi Narita, Yoshihide Tsujimoto, Yoshihide Tsujimoto, Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC Nature. ,vol. 399, pp. 483- 487 ,(1999) , 10.1038/20959
Richard S. Hotchkiss, Kevin W. McConnell, Kristin Bullok, Christopher G. Davis, Katherine C. Chang, Steven J. Schwulst, Jeffrey C. Dunne, Gunnar P. H. Dietz, Mathias Bähr, Jonathan E. McDunn, Irene E. Karl, Tracey H. Wagner, J. Perren Cobb, Craig M. Coopersmith, David Piwnica-Worms, TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. Journal of Immunology. ,vol. 176, pp. 5471- 5477 ,(2006) , 10.4049/JIMMUNOL.176.9.5471
Guido Kroemer, Lorenzo Galluzzi, Catherine Brenner, Mitochondrial Membrane Permeabilization in Cell Death Physiological Reviews. ,vol. 87, pp. 99- 163 ,(2007) , 10.1152/PHYSREV.00013.2006
Steven W. Muchmore, Michael Sattler, Heng Liang, Robert P. Meadows, John E. Harlan, Ho Sup Yoon, David Nettesheim, Brian S. Chang, Craig B. Thompson, Sui-Lam Wong, Shi-Chung Ng, Stephen W. Fesik, X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature. ,vol. 381, pp. 335- 341 ,(1996) , 10.1038/381335A0
Soumya Sinha Roy, Muniswamy Madesh, Erika Davies, Bruno Antonsson, Nika Danial, György Hajnóczky, Bad Targets the Permeability Transition Pore Independent of Bax or Bak to Switch between Ca2+-Dependent Cell Survival and Death Molecular Cell. ,vol. 33, pp. 377- 388 ,(2009) , 10.1016/J.MOLCEL.2009.01.018
Shuichi Saito, Yukio Hiroi, Yunzeng Zou, Ryuichi Aikawa, Haruhiro Toko, Futoshi Shibasaki, Yoshio Yazaki, Ryozo Nagai, Issei Komuro, β-Adrenergic Pathway Induces Apoptosis through Calcineurin Activation in Cardiac Myocytes Journal of Biological Chemistry. ,vol. 275, pp. 34528- 34533 ,(2000) , 10.1074/JBC.M002844200
Jacob M. Gump, Steven F. Dowdy, TAT transduction: the molecular mechanism and therapeutic prospects Trends in Molecular Medicine. ,vol. 13, pp. 443- 448 ,(2007) , 10.1016/J.MOLMED.2007.08.002
Richard J. Youle, Andreas Strasser, The BCL-2 protein family: opposing activities that mediate cell death Nature Reviews Molecular Cell Biology. ,vol. 9, pp. 47- 59 ,(2008) , 10.1038/NRM2308
Hong-Gang Wang, Nuzhat Pathan, Iryna M Ethell, Stanislaw Krajewski, Yu Yamaguchi, Futoshi Shibasaki, Frank McKeon, Tanya Bobo, Thomas F Franke, John C Reed, Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science. ,vol. 284, pp. 339- 343 ,(1999) , 10.1126/SCIENCE.284.5412.339