A Role for Neutral Sphingomyelinase-mediated Ceramide Production in T Cell Receptor–induced Apoptosis and Mitogen-activated Protein Kinase–mediated Signal Transduction
作者： Laura Tonnetti , Maria-Concetta Verí , Ezio Bonvini , Luciano D'Adamio
关键词: Ceramide 、 Signal transduction 、 T cell 、 Cell biology 、 Sphingomyelin 、 Lipid signaling 、 T-cell receptor 、 Jurkat cells 、 Sphingomyelin phosphodiesterase 、 Biology
摘要: Studying apoptosis induced by T cell receptor (TCR) cross-linking in the hybridoma, 3DO, we found both neutral sphingomyelinase activation and production of ceramide upon engagement. Pharmacological inhibition fungal toxin, fumonisin B1, impaired TCR-induced interleukin (IL)-2 programmed death. Addition either exogenous or bacterial reconstituted responses. Moreover, specific inactivation antisense RNA inhibited IL-2 mitogen-activated protein kinase after TCR triggering. These results suggest that is an essential component signaling machinery.
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