CNS mechanisms of alcohol self-administration

摘要: Neurochemical and neuropharmacological studies were undertaken to examine the possible involvement of ventral tegmental area (VTA) dopamine (DA) system dorsal raphe nucleus (DRN) serotonin (5-HT) in regulating oral alcohol self-administration. In vivo microdialysis demonstrated that either i.p. ethanol administration (1.0-2.0 g/kg) or local perfusion with (100 mM) could enhance extracellular concentrations both DA 5-HT accumbens (ACB). Furthermore, effects on release ACB be blocked by co-perfusion a 5-HT3 antagonist. selectively-bred preferring P line rats, there appears abnormal and/or systems certain limbic structures, i.e., ACB, olfactory tubercles (OTU) medial prefrontal cortex (MPF). This is indicated (a) lower contents 5-HT; (b) fewer immunostained fibers; (c) densities 5-HT1B, 5-HT2 D2 receptors; (d) higher 5-HT1A receptors CNS rats compared alcohol-nonpreferring NP rats. Neuropharmacological microinfusion antagonist, sulpiride, or, at low doses, releaser, d-amphetamine, increase drinking Intracranial self-administration (ICSA) showed but not line, will self-administer 50-150 mg% directly into VTA. Overall, these results suggest an innate functioning VTA DRN may key factors facilitating rewarding actions Language: en